Matisse's cut-outs, which transformed 20th century art, were done from a wheelchair when he could not hold a paintbrush at arm's length. This led him to design the amazing chapel at Vence, France that has become a landmark building. This unique exhibition, staged to coincide with the Olympics and Paralympics, will show how challenge can lead to great artistic achievements.

All of the artists on display have attained new levels in art as a result of overcoming their own personal challenges. Indeed, they are the catalyst for their genius, enriching and energising their work.

The exhibition looks at inspiring examples from the 18th century through to the present day and will feature works including Henri Matisse, Anne Killigrew, Thomas Luny, Nerys Johnson, Tom Early, Bryan Pearce, Patrick Woodroffe and Edward Lear.